Solvent-Assisted Secondary Drying of Spray-Dried Polymers

Effects of Spray Drying and Spray Chilling on Ibuprofen Dissolution

       The formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. Consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. Microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a ...

Emergence of secondary motifs in tubelike polymers in a solvent.

We study the effects of two kinds of interactions in tubelike polymers and demonstrate that they result in the formation of secondary motifs. The first has an entropic origin and is a measure of the effective space available to the solvent. The second arises from solvophobic interactions of the solvent with the polymers and leads to an energy proportional to the contact surface between the tube...

Mechanistic Understanding of Spray Drying

Purpose Spray drying is a growing technology in the pharmaceutical industry with several enabling applications in modern drug delivery. Its understanding is still vastly empirical, mainly in what relates to the particle formation step. Consequently, the design spaces are typically defined through costly experiments and their statistical interpretation. The purpose of this study is to examine th...

Spray-Dried Lactose

pray-dried (SD) lactose was introduced to the pharmaceutical market in the 1960s as an excipient that enables direct compression of formulations in a simple manufacturing process (1). To this day, lactose remains one of the most popular excipients for active pharmaceutical ingredients (APIs) whose dose makes them suitable for direct compression. Several manufacturers make and sell SD lactose, a...

Effect of Drying Conditions on Properties of Dried Sugar Beet